Martí Mestieri's research lies at the intersection of macroeconomics and development economics. He is particularly interested in human capital acquisition and technology adoption. His research topics include the design of educational systems in the presence of private information and borrowing constraints, the effects of the IT revolution on wage inequality and the pattern of specialization, and the study of the interplay between technology diffusion and economic development.

Mestieri received a Llicenciatura in Physics and a Llicenciatura in Economics from Universitat Autònoma de Barcelona in 2002 and 2006 respectively, and a Ph.D. in Economics from the Massachusets Institute of Technology in 2011.