This study examines the effects of a home visiting program for first-time disadvantaged mothers on mother-child interactions. A sample of 109 dyads participating in the Pro Kind trial was videotaped during a 3-min typical play situation at the participants’ homes when the child was aged 25 months, and assessed for orientation and contingency. The results show a significant improvement of the interactions between girls and their mothers, by increasing both the persistence of girls’ positive behaviors (even in the absence of mothers’ positive behaviors). No positive impacts were detected for the boys. These results have important implications for the analysis of mother-child interactions data and the design of home visiting programs.